Lymphocyte traffic and graft-versus-host disease after fully allogeneic small bowel transplantation.
نویسندگان
چکیده
منابع مشابه
Graft-versus-host disease in fully allogeneic small bowel transplantation: incidence of the disease and strain combinations.
WE PREVIOUSLY reported that fully allogeneic small bowel transplantation (SB11 from Lewis (LEW) to Brown Norway (BN) rats caused fatal graftversus-host disease (GVHD) when the recipients were treated with a short course of FK 506. 1 Graft-versus-host disease has also been well described after parent to F 1 hybrid SBT,2 in which immune reaction between donor and recipient is completely unbalance...
متن کاملPersistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation.
GRAFf-versus-host disease (GVHD) has always been a concern associated with small bowel transplantation, because of the large amount of matured lymphocytes contained in the graft. In clinical organ transplantation GVHD is not a common complication; however, it is usually fatal once developed. Because there is no suitable experimental model of GVHD associated with solid organ transplantation, stu...
متن کاملExperimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies.
ALTHOUGH graft-versus-host disease (GVHD) has been a major concern after small-bowel transplantation (SBTX), the lack of suitable experimental model has allowed only limited study of GVHD after solid-organ transplantation. l We recently developed a clinically relevant experimental animal model of GVHD of fully allogeneic SBTX. This study describes histopathological evolution of the disease. cyt...
متن کاملChronic graft versus host disease with small bowel obstruction after unrelated hematopoietic stem cell transplantation in a patient with acute myeloid leukemia
Chronic graft versus host disease (GVHD) is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), but simultaneous small bowel obstruction is rare. Here, we report a child with acute myeloid leukemia who received an allogeneic HSCT from an unrelated matched donor. After HSCT, the patient developed severe chronic GVHD involving the small intestine, leading to o...
متن کاملAssessment of Cyclosporine Serum Concentrations on the Incidence of Acute Graft versus Host Disease Post Hematopoietic Stem Cell Transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological disorders. Cyclosporine (CsA) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (GvHD). In this retrospective study, we evaluated the effects of CsA serum levels on the incidence of acute GvHD and transplant outcomes. 103 adult patients rece...
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 23 6 شماره
صفحات -
تاریخ انتشار 1991